Flow chart illustrating the screening steps and resulting substance numbers for the publicly available REACH database. Classification of organic, non-ionic substances according to their persistence (vP - very persistent, P - persistent, or ¬P - not persistent), bioaccumulation potential (vB - very bioaccumulative, B - bioaccumulative, or ¬B - not bioaccumulative), and LRTP. Percentages given in brackets refer to the respective numbers of substances, which resulted from the previous step. Dashed lines separate the number of substances which fail the respective following criterion by not more than 10%, e.g. 5 of 104 substances which are ¬P fail the P criterion by not more than 10%.