Table 2 PBT-assessment of PFOA
Relevant criteria for the identification of PFOA as PBT-substances (Extract of Annex XIII of the REACH regulation) | Concerns of PFOA | Reference | |
|---|---|---|---|
P | DT50 (marine water) > 60 d DT50 (fresh or estuarine water) > 40 d DT50 (marine sediment) > 180 d DT50 (fresh or estuarine sediment) > 120 d DT50 (soil) > 120 d | No measurable half-lives available because of the high persistence | |
B | BCF > 2000 | BCF 1.8 – 27 | |
Bioaccumulation in terrestrial and aquatic species Biomagnification in the food chain, i.e. biomagnification or trophic magnification factors (BMF, TMF) | BAF 0.04 - 29 2BMF (marine) 0.02 – 125 BMF (terrestrial) 0.9 – 11 TMF (marine) 0.3 – 13 TMF (terrestrial) 1.1 – 2.4 | ||
Analysis of human body fluids or tissues, such as blood, milk, or fat | < 0.15 – 0.25 μg L-1 in breast milk | [89] | |
Elevated levels in biota, in particular in endangered species or in vulnerable populations | up to 3.4 ng g−1 ww in polar bear livers | [1] | |
T | Long-term no-observed effect concentration (NOEC)< 0.01 mg L−1Classification as carcinogenic (category 1A or 1B), germ cell mutagenic (category 1A or 1B), or toxic for reproduction (category 1A, 1B, or 2) (according to EC No 1272/2008) | chronic toxicity, i.e. 30 d-NOEC = 100 mg L−1 for Pimephales promelas Repr. 1B | |
Other evidence of chronic toxicity, i.e. specific target organ toxicity after repeated exposure (STOT RE category 1 or 2) (according to EC No 1272/2008) | STOT RE 1 |