Toxicology of perfluorinated compounds

Stahl, Thorsten; Mattern, Daniela; Brunn, Hubertus

doi:10.1186/2190-4715-23-38

Environmental Sciences Europe

Table 31 Results of studies on reproduction toxicological effects of PFCs on humans

From: Toxicology of perfluorinated compounds

Effects	Study population	Results	Reference
Birth weight	Occupationally exposed women, USA	No correlation between extent of PFOS exposure and birth weight	Grice et al. [248]
	General population, Japan	No correlation between PFOS concentration in cord blood and birth weight	Inoue et al. [54]
	General population, Danish National Cohort	Correlation between the PFOA concentration in mother's plasma and birth weight; not detectable for PFOS	Fei et al. [57]
	General population, USA	Weak inverse correlation between concentrations of PFOS and PFOA in cord blood and birth weight	Apelberg et al. [55]
	General population, Canada	No correlation of PFC serum concentrations and birth weight	Monroy et al. [56]
	General population, Japan, 2002 to 2005	Negative correlation of in utero exposure to PFOS birth weight; not detectable for PFOA	Washino et al. [272]
	General population, USA	No indication of a connection between low birth weight and PFOA-contaminated drinking water	Nolan et al. [274]
	General population, USA, 2000 to 2006	Correlation between PFOS contamination and the risk of reduced birth weight	Stein et al. [276]
	General population, Canada	No correlation between PFOA, PFHxS, PFOS serum concentrations and birth weight	Hamm et al. [273]
Gestation time	General population, Danish National Cohort	No correlation of PFOA and PFOS concentrations in mother's plasma with time of gestation	Fei et al. [57]
	General population, USA	No indication of premature birth as a result of PFOA contamination via drinking water	Nolan et al. [274]
	General population, USA, 2000 to 2006	No connection of PFOS or PFOA serum concentration with miscarriage or premature birth	Stein et al. [276]
	General population, Canada	No correlation between PFOA, PFHxS, PFOS serum concentrations and gestation time	Hamm et al. [273]
Development	General population, Danish National Cohort	No difference in the development of newborns from mothers with high PFOA and PFOS concentrations and children of mothers with low PFOA and PFOS concentrations; sitting without support possibly delayed in children of mothers with high PFOS concentrations	Fei et al. [277]
Other aspects	General population, USA	Weak inverse correlation between concentrations of PFOS and PFOA in cord blood and the ponderal index or head circumference	Apelberg et al. [55]
	General population, Japan	No correlation between PFOS concentration in cord blood and concentration of thyroid hormones	Inoue et al. [54]
	General population, USA, 2000 to 2006	Weak correlation of PFOA concentrations and occurrence of miscarriages	Stein et al. [276]
	General population, USA, 2000 to 2006	Weak association of PFOA and PFOS serum concentrations with the occurrence of preeclampsia	Stein et al. [276]
	General population, 571 children between 12 to 15 years from the NHANES study, 1999 to 2000 and 2003 to 2004	Increased risk of ADHD for children with elevated PFOS, PFOA, PFHxA, and PFNA serum concentrations	Hoffman et al. [280]
Fertility	General population, Danish National Birth Cohort, 1996 to 2002	Fertility disorders related to elevated PFOA and PFOS plasma concentrations	Fei et al. [278]

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