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Table 26 Effects on rats after a 104-week application of APFO (from Sibinski [150]; EFSA [15])

From: Toxicology of perfluorinated compounds

Category

Effects

Animal, dosage, in part frequency (Cases/Total number)

Non-neoplastic effects

(a) Slight reduction in number of erythrocytes and packed cell volume, liver mass, liver nodules, Leydig cell mass ↑; (b) number of white blood cells ↑ and AST, ALT, alkaline phosphatase, and creatine phosphokinase ↑; (c) breast tissue mass ↑ and tubular hyperplasia of the ovarian stroma; (d) kidney mass ↑ and changes in the liver (hepatomegalocytosis, necrosis, mononuclear cell infiltration, cystoid degeneration)

(a) Male rats, 300 mg/kg

(b) Male rats, 30 mg/kg

(c) Female rats, 30 mg/kg

(d) Female rats, 300 mg/kg

Carcinogenicity

(a) Incidences of testicular Leydig cell adenomas ↑ and (b) fibrocystic breast adenomas ↑

(a) Male rats, 0 mg/kg (0/50), 30 mg/kg (2/50), 300 mg/kg (7/50)

(b) Female rats, 0 mg/kg (10/46), 30 mg/kg (19/45), 300 mg/kg (21/44)

  1. Upward arrow, increased.