Toxicology of perfluorinated compounds

Environmental Sciences Europe

Table 23 Changes in male and female cynomolgus monkeys after daily application of various dosages of PFOS

Change	PFOS dosage (mg/kg BW)
	0	0.03	0.15	0.75
Increased mortality				× ^a
Vacuolization and hypertrophy of the liver				× ○
TSH level increased			×	× ○
T₃ level lowered		○	×	× ○
HDL concentration lowered		×	○	× ○
Bilirubin concentration dropping				×
Cholesterol concentration dropping				× ○

Changes in male (cross) and female (empty circle) monkeys; ^atwo of six animals. Adapted from Seacat et al. [128]; BfR [17].