Toxicology of perfluorinated compounds

Table 21 LD₅₀ and LC₅₀ values for PFOS and PFOA (from [15]; BfR [17] enhanced)

Criterion	PFOS	PFOA	Animal species	Reference
LD₅₀	251 mg/kg BW	430 to 680 mg/kg BW	Rat	Dean and Jessup [287]
LC₅₀	5.2 mg/L, inhalative	0.98 mg/L, inhalation	Rat	Kennedy [100]
LD₅₀	n.r.	4, 300 mg/kg APFO, dermal	Rabbit	Kennedy [99]
LD₅₀	n.r.	7, 000 mg/kg 7, 500 mg/kg, dermal	Male rats Female rats	Kennedy [99]
LC₅₀	n.r.	2, 000 mg/kg, dermal	Rabbit	Glaza et al. [135]
48 h-LC₅₀ 96 h-LC₅₀	27 to 233 mg/L 10 to 178 mg/L	181 to 732 mg/L 337 to 672 mg/L	Four fresh water species (water flea, water snail, shrimp, planarian)	Li [288]
LC₅₀	18 mg/L	200 mg/L	Japanese water flea	Ji et al. [137]