Comparison of four different methods for reliability evaluation of ecotoxicity data: a case study of non-standard test data used in environmental risk assessments of pharmaceutical substances

Environmental Sciences Europe

Table 2 Overview of the non-standard effect data evaluated in this study.

Reference	Pharmaceutical substance	Endpoint	Test species and effect value
Andreozzi et al. [14]	Amoxicillin	Growth inhibition	Synechococcus leopoliensis NOEC (96 h) 0.78 μg/L
Ferrari et al. [15]	Ofloxacin	Growth inhibition	Synechococcus leopolensis EC₅₀ (96 h) 16 μg/L
Ferrari et al. [15]	Sulfamethoxazole	Growth inhibition	Synechococcus leopoliensis EC₅₀ (96 h) 26.8 μg/L
Ferrari et al. [15]	Propranolol	Growth inhibition	Pseudokirchneriella subcapitata NOEC (96 h) 5 mg/L Synechococcus leopolensis NOEC (96 h) 0.35 mg/L
Huggett et al. [16]	Propranolol	Number of eggs and percent hatch	Oryzias latipes LOEC (4 weeks) 0.5 μg/L
Robinson et al. [17]	Levofloxacin	Growth inhibition	Pseudokirchneriella subcapitata EC₅₀ (72 h) 7.4 mg/L
Schmitt-Jansen et al. [18]	Diclofenac	Cell reproduction	Scenedesmus vacuolatus EC₅₀ (24 h) 0.023 mg/L
Quinn et al. [19]	Ibuprofen	Morphology changes	Hydra attenuata EC₅₀ (96 h) 1.65 mg/L
Metcalfe et al. [20]	Estradiol	Induced intersex (testis-ova)	Oryzias latipes NOEL (90 days) 0.0004 μg/L
Nentwig [21]	Fluoxetine	Reproduction inhibition	Potamopyrgus antipodarum NOEC (56 days) 0.47 μg/L
Halm et al. [22]	Estradiol	P450aromB mRNA expression in the brain	Pinephales promelas LOEC (4 days) 100 ng/L

NOEC/L no observed effect concentration/level, LOEC lowest observed effect concentration, EC₅₀lowest identified effect concentration where 50% of the tested population have been found to be affected.