Table 11 OECDs reporting requirements, modified evaluation criteria/questions concerning biological effect, and summary of the evaluation results.
Evaluation method | Evaluation criteria/question | Type of criteria/mark | Summary of evaluation results |
|---|---|---|---|
Klimisch et al. | Determined effect concentrations (EC/LC/NOEC/LOEC). | Recommended | Not stated in one study but could be understood. |
Durda and Preziosi | Quantitative measurement of response. | Recommended | Stated in all studies. |
Results reproduced by others. | Recommended | Not considered. | |
Consistent with other findings. | Recommended | Not considered. | |
Dose-response observed. | Recommended | Not stated in three studies, no relationship in one study. | |
Hobbs et al. | Was the biological effect stated (e.g., LC or NOEC)? | 0 or 5 | Not stated in one study but could be understood. |
Was the biological effect quantified (e.g., 50% effect, 25% effect)? The effect for NOEC and LOEC data must be quantified. | 0 or 5 | Info about tested concentrations is missing for one LOEC/NOEC value. | |
Was there a concentration-response relationship either observable or stated? | 0 or 4 | Not stated in three studies, no relationship for one study. | |
Schneider et al. | Is the description of the study results for all endpoints investigated transparent and complete? | Recommended, 0, or 1 | Not stated in four studies. |
OECD guidelines | Concentration-response data, the slope of the dose-response curve and its standard error; EC50 or EC10 and associated confidence intervals; LOEC and NOEC and the statistical methods used for their determination; calculated response variables for each treatment replicate, with mean values and coefficient of variation for replicates. | Mandatory | The non-standard studies were not evaluated according to the OECD reporting requirements. |