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Table 1 The lowest publically available standard and non-standard effect values for ethinylestradiola.

From: Comparison of four different methods for reliability evaluation of ecotoxicity data: a case study of non-standard test data used in environmental risk assessments of pharmaceutical substances

Test standard

Test species

Endpoint

Effect values

Reference

OECD 201b

Desmodesmus spp (algae)

Growth inhibition

EC50 0.13 mg/L NOEC <0.1 mg/L

[34]

OECD 210b (modified)

Danio rerio (fish)

Condition factor (comprising effects on weight and length)

NOEC 0.00001 mg/Lc

[35]

OECD 211b

Daphnia (crustacean)

Reproduction

EC50 0.105 mg/L

[36]

Non-standard test

Danio rerio (fish)

Spawning, egg production, fertilization

NOEC 0.00000031 mg/L

[37]

Non-standard test

Danio rerio (fish)

Fertilization success

EC50 0.0000011 mg/L

[38]

  1. aAccording to the Wikipharma database [3] and the environmental classification system at http://www.fass.se[4]. bRecommended for use in environmental risk assessments of pharmaceuticals (EMA, 2006); cThe highest tested concentration.
  2. OECD Organisation for Economic Cooperation and Development, NOEC no observed effect concentration. EC50 lowest identified effect concentration where 50% of the tested population have been found to be affected.