Genetically modified crops safety assessments: present limits and possible improvements

Environmental Sciences Europe

Table 1 Review of the longest chronic or subchronic toxicity studies in mammals fed with commercialized GM soybean and maize representing more than 80% of edible GMOs (2010).

References	Plant	Pesticide contained	Name of event	Species	Duration	Main observations
[17, 38, 39, 19, 15]	Soybean	Roundup herbicide	mCP4 EPSPS	Mouse	240 days	Ultrastructural histochemistry disturbed
[14]	Soybean	Roundup herbicide	mCP4 EPSPS	Rat	91 days	Weight problems
[40]	Soybean	Roundup herbicide	Optimum GAT DP-356Ø43-5	Rat	93 days	Statistical differences^a
[41]	Soybean	Roundup herbicide	Not precise	Rat	104 weeks	Statistical differences^a
[42]	Maize	Roundup herbicide	Optimum GAT DP-Ø9814Ø-6	Rat	91 days	Statistical differences^a
[43, 5]	Maize	Roundup herbicide	NK603	Rat	90 days	Controversial results
[44, 5]	Maize	mCry1Ab insecticide	MON810	Rat	90 days	Controversial results
[25, 2, 4, 5]	Maize	mCry3Bb1 insecticide	MON863	Rat	90 days	Controversial results
[16]	Maize	mBt insecticide	not indicated	Rat	Multi- generational (F3)	Histopathological, biochemical, organ weights alterations
[45]	Maize	mCry1F insecticide - glufosinate ammonium-based herbicide	DAS-Ø15Ø7-1	Rat	91 days	Statistical differences^a
[46, 47]	Maize	mCry34Ab1, mCry35Ab1 insecticides - glufosinate ammonium-based herbicide	DAS-59122-7	Rat	90 days	Statistical differences^a
[48]	Maize	mCry1F, mCry34Ab1, mCry35Ab1 insecticides - glufosinate ammonium-based herbicide	DAS-Ø15Ø7-1 × DAS-59122-7	Rat	92 days	Statistical differences^a

^aStatistical differences are not biologically meaningful for the authors; however, this can be debated. Oilseed rape and cotton have been excluded because they are not directly edible and not primarily grown for feed. This table includes authorized events for food and feed at least in the European Union and America.