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Table 1 Review of the longest chronic or subchronic toxicity studies in mammals fed with commercialized GM soybean and maize representing more than 80% of edible GMOs (2010).

From: Genetically modified crops safety assessments: present limits and possible improvements

References Plant Pesticide contained Name of event Species Duration Main observations
[17, 38, 39, 19, 15] Soybean Roundup herbicide mCP4 EPSPS Mouse 240 days Ultrastructural histochemistry disturbed  
[14] Soybean Roundup herbicide mCP4 EPSPS Rat 91 days Weight problems  
[40] Soybean Roundup herbicide Optimum GAT DP-356Ø43-5 Rat 93 days Statistical differencesa  
[41] Soybean Roundup herbicide Not precise Rat 104 weeks Statistical differencesa  
[42] Maize Roundup herbicide Optimum GAT DP-Ø9814Ø-6 Rat 91 days Statistical differencesa  
[43, 5] Maize Roundup herbicide NK603 Rat 90 days Controversial results  
[44, 5] Maize mCry1Ab insecticide MON810 Rat 90 days Controversial results  
[25, 2, 4, 5] Maize mCry3Bb1 insecticide MON863 Rat 90 days Controversial results  
[16] Maize mBt insecticide not indicated Rat Multi- generational (F3) Histopathological, biochemical, organ weights alterations  
[45] Maize mCry1F insecticide - glufosinate ammonium-based herbicide DAS-Ø15Ø7-1 Rat 91 days Statistical differencesa  
[46, 47] Maize mCry34Ab1, mCry35Ab1 insecticides - glufosinate ammonium-based herbicide DAS-59122-7 Rat 90 days Statistical differencesa  
[48] Maize mCry1F, mCry34Ab1, mCry35Ab1 insecticides - glufosinate ammonium-based herbicide DAS-Ø15Ø7-1 × DAS-59122-7 Rat 92 days Statistical differencesa  
  1. aStatistical differences are not biologically meaningful for the authors; however, this can be debated. Oilseed rape and cotton have been excluded because they are not directly edible and not primarily grown for feed. This table includes authorized events for food and feed at least in the European Union and America.