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Environmental Sciences Europe

Table 2 EC50 values in the Yeast Anti-Estrogen Screen (YAES)

From: Regrettable substitution? Comparative study of the effect profile of bisphenol A and eleven analogues in an in vitro test battery

YAES

BPA

BPB

BPE

BPF

BPS

BPZ

BPAF

BPAP

BPBP

BADGE

TBBPA

TCBPA

EC50 (mg/L)

        

0.866

2.69

0.789

 

95% confidence interval (mg/L)

        

0.656–1.08

2.13–3.26

0.688–0.890

 

Specific activity (M)

        

2.46 × 10−6

7.90 × 10−6

1.45 × 10−6

 

Maximum relative activity (%)

        

60.7

39.7

91.5

 

Significance to BPA

        

↓

↓

↓

 
  1. Displayed are the 50% effect concentrations (EC50) (mg/L) with the respective 95% confidence interval (mg/L), specific activity (M), maximum anti-estrogenic induction (%), and the significant difference to BPA for each bisphenol. The specific activity is calculated using Eq. 1. The significant difference to BPA is determined through non-overlapping confidence intervals. Bold arrows pointing downwards indicate a significantly lower EC50 than BPA, arrows pointing upwards indicate a significantly higher EC50. Bisphenols with no values did not show an effect at the tested concentrations
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