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Table 4 Association of pesticide exposure with cancer based on subgroup of oxidative stress marker level

From: Pesticides, cancer, and oxidative stress: an application of machine learning to NHANES data

   

Colon cancer

Skin cancer (non-melanoma)

Melanoma

Skin cancer (other types)

Prostate cancer

Breast cancer

Cervix cancer

P value

2,4-D

ALT (U/L)

1

 

3.469 (3.448–3.490)

1.344 (1.340–1.348)

1.083 (1.079–1.087)

13.314 (13.314–13.496)

0.400 (0.399–0.400)

5.540 (5.495–5.586)

0.001

  

2

0.692 (0.689–0.696)

0.596 (0.594–0.598)

0.39 (0.389–0.391)

3.442 (3.425–3.460)

1.248 (1.242–1.253)

1.296 (1.293–1.300)

0.318 (0.317–0.319)

 
  

3

1.29 (1.285–1.294)

0.504 (0.501–0.506)

6.595 (6.568–6.622)

0.348 (0.347–0.349)

3.148 (3.127–3.169)

0.342 (0.341–0.343)

3.379 (3.357–3.400)

 
  

4

2.917 (2.886–2.949)

1.169 (1.160–1.178)

1.369 (1.365–1.372)

4.737 (4.702–4.773)

 

0.960 (0.959–0.960)

  
 

AST (U/L)

1

  

2.254 (2.244–2.264)

5.142 (5.108–5.177)

3.613 (3.583–3.643)

0.614 (0.612–0.615)

0.924 (0.921–0.927)

 
  

2

1.105 (1.101–1.109)

1.545 (1.538–1.552)

1.688 (1.684–1.693)

1.017 (1.013–1.021)

1.388 (1.382–1.395)

0.360 (0.359–0.361)

0.770 (0.767–0.773)

 
  

3

1.299 (1.292–1.306)

0.125 (0.124–0.126)

0.857 (0.855–0.858)

0.574 (0.573–0.576)

5.467 (5.427–5.507)

0.865 (0.863–0.867)

1.014 (1.009–1.019)

 
  

4

4.119 (4.087–4.151)

1.836 (1.822–1.850)

1.050 (1.048–1.053)

3.301 (3.276–3.326)

9.143 (9.047–9.241)

1.775 (1.768–1.782)

3.411 (3.384–3.438)

 
 

GGT (U/L)

1

0.269 (0.267–0.270)

1.275 (1.269–1.281)

1.525 (1.522–1.529)

1.273 (1.268–1.277)

 

0.668 (0.667–0.670)

0.260 (0.259–0.261)

 
  

2

  

0.642 (0.641–0.643)

 

1.143 (1.137–1.148)

0.914 (0.911–0.916)

  
  

3

2.681 (2.666–2.697)

0.59 (0.58–0.59)

1.073 (1.070–1.076)

0.742 (0.739–0.744)

8.740 (8.654–8.827)

0.568 (0.567–0.570)

1.359 (1.350–1.367)

 
  

4

3.368 (3.346–3.389)

0.136 (0.135–0.137)

 

0.389 (0.388–0.391)

2.365 (2.352–2.378)

0.506 (0.505–0.507)

7.023 (6.969–7.078)

 

4-fluoro-3-phenoxybenzoic

AST (U/L)

1

1.805 (1.788–1.823)

 

1.762 (1.753–1.771)

 

7.705 (7.667–7.743)

0.225 (0.223–0.227)

2.092 (2.082–2.101)

0.001

  

2

1.452 (1.445–1.459)

3.533 (3.519–3.547)

0.863 (0.859–0.866)

0.667 (0.663–0.671)

0.692 (0.687–0.697)

0.473 (0.470–0.475)

  
  

3

  

2.183 (2.178–2.188)

 

0.965 (0.960–0.970)

1.460 (1.454–1.465)

20.837 (20.744–20.932)

 
  

4

3.821 (3.804–3.838)

 

0.441 (0.439–0.443)

 

0.420 (0.416–0.424)

1.770 (1.763–1.778)

  
 

Iron, refigerated (μmol/L)

1

3.132 (3.106–3.158)

1.002 (1.002–1.002)

1.627 (1.623–1.632)

  

1.481 (1.476–1.485)

3.017 (3.002–3.031)

 
  

2

2.328 (2.315–2.340)

 

1.530 (1.526–1.534)

 

0.465 (0.461–0.468)

0.353 (0.350–0.356)

  
  

3

 

5.051 (5.027–5.075)

0.471 (0.468–0.473)

0.651 (0.647–0.655)

2.538 (2.524–2.553)

1.356 (1.351–1.362)

21.223 (21.128–21.319)

 
  

4

1.956 (1.948–1.964)

1.686 (1.676–1.697)

1.230 (1.226–1.235)

 

6.596 (6.567–6.625)

   

3-phenoxybenzoic acid

ALT (U/L)

1

0.682 (0.678–0.685)

1.456 (1.447–1.465)

0.279 (0.278–0.279)

4.553 (4.517–4.590)

0.367 (0.366–0.369)

1.094 (1.091–1.097)

 

0.001

  

2

0.671 (0.667–0.675)

0.315 (0.314–0.316)

0.247 (0.246–0.247)

1.563 (1.556–1.571)

4.697 (4.655–4.740)

0.552 (0.550–0.553)

0.699 (0.697–0.701)

 
  

3

12.524 (12.379–12.672)

0.583 (0.580–0.586)

2.192 (2.185–2.199)

0.641 (0.638–0.643)

7.433 (7.355–7.513)

0.944 (0.941–0.948)

3.788 (3.755–3.822)

 
  

4

2.302 (2.274–2.330)

 

0.841 (0.839–0.843)

0.901 (0.897–0.905)

1.310 (1.303–1.317)

0.188 (0.187–0.188)

  
 

GGT (U/L)

1

0.932 (0.926–0.938)

0.660 (0.657–0.663)

0.466 (0.465–0.467)

0.592 (0.590–0.594)

 

0.541 (0.540–0.543)

0.490 (0.489–0.492)

 
  

2

0.894 (0.888–0.900)

2.125 (2.113–2.137)

0.527 (0.526–0.528)

 

0.565 (0.563–0.568)

0.445 (0.444–0.447)

  
  

3

0.861 (0.856–0.865)

0.027 (0.027–0.028)

0.454 (0.452–0.455)

1.040 (1.036–1.044)

 

1.874 (1.865–1.883)

  
  

4

  

1.270 (1.265–1.274)

1.495 (1.486–1.503)

1.150 (1.145–1.156)

0.608 (0.606–0.609)

  
 

Iron, refigerated (μmol/L)

1

 

0.049 (0.049–0.050)

0.498 (0.496–0.499)

 

0.800 (0.796–0.803)

0.370 (0.369–0.371)

  
  

2

1.071 (1.065–1.077)

0.276 (0.275–0.277)

0.202 (0.202–0.203)

2.249 (2.238–2.260)

1.345 (1.338–1.353)

1.018 (1.014–1.021)

0.586 (0.584–0.588)

 
  

3

  

1.054 (1.050–1.057)

0.938 (0.934–0.941)

 

1.437 (1.432–1.443)

  
  

4

1.379 (1.374–1.385)

  

0.508 (0.506–0.510)

5.698 (5.637–5.759)

0.510 (0.509–0.512)

  
 

Uric acid (mg/dL)

1

0.777 (0.772–0.783)

0.329 (0.327–0.330)

0.252 (0.252–0.253)

1.952 (1.938–1.966)

 

1.976 (1.968–1.984)

5.525 (5.477–5.574)

 
  

2

 

0.490 (0.488–0.493)

0.372 (0.371–0.373)

1.742 (1.732–1.753)

0.266 (0.264–0.267)

1.210 (1.206–1.215)

  
  

3

0.558 (0.555–0.562)

1.798 (1.787–1.808)

2.187 (2.179–2.195)

1.244 (1.239–1.249)

7.846 (7.764–7.930)

0.218 (0.217–0.219)

0.035 (0.034–0.035)

 
  

4

1.703 (1.694–1.712)

0.557 (0.554–0.561)

0.884 (0.882–0.886)

0.668 (0.666–0.671)

1.629 (1.622–1.637)

0.392 (0.391–0.393)

  

Oxypyrimidine

AST (U/L)

1

0.438 (0.432–0.443)

 

0.085 (0.084–0.086)

 

0.501 (0.497–0.505)

0.718 (0.715–0.721)

 

0.001

  

2

1.722 (1.716–1.728)

0.986 (0.982–0.990)

0.406 (0.404–0.407)

1.928(1.921–1.934)

1.872 (1.865–1.880)

1.123 (1.119–1.126)

1.638 (1.631–1.645)

 
  

3

0.830 (0.825–0.834)

0.095 (0.093–0.096)

0.153 (0.153–0.154)

1.378(1.374–1.382)

1.737 (1.731–1.744)

2.093 (2.088–2.099)

5.878 (5.852–5.904)

 
  

4

0.358 (0.355–0.361)

 

1.003 (1.000–1.005)

0.399(0.396–0.402)

4.416 (4.400–4.432)

2.362 (2.355–2.370)

4.974 (4.950–4.999)

 
 

GGT (U/L)

1

0.212 (0.209–0.215)

1.486 (1.480–1.493)

0.501 (0.500–0.503)

 

0.256 (0.254–0.258)

1.607 (1.603–1.612)

0.947 (0.943–0.951)

 
  

2

 

0.076 (0.075–0.077)

0.309 (0.307–0.310)

4.180(4.165–4.194)

2.726 (2.714–2.739)

1.005 (1.001–1.009)

  
  

3

0.114 (0.112–0.115)

 

0.479 (0.477–0.481)

0.67(0.667–0.673)

2.963 (2.952–2.974)

2.089 (2.082–2.095)

  
  

4

3.349 (3.338–3.361)

 

0.391 (0.390–0.393)

2.160(2.152–2.169)

3.053 (3.042–3.063)

1.173 (1.170–1.176)

5.845 (5.825–5.865)

 

Paranitrophenol

Iron, refigerated (μmol/L)

1

  

0.624 (0.622–0.626)

 

3.072 (3.036–3.109)

0.532 (0.530–0.534)

 

0.001

  

2

0.633 (0.629–0.638)

0.331 (0.330–0.333)

0.865 (0.862–0.868)

   

1.002 (0.997–1.008)

 
  

3

0.581 (0.576–0.586)

 

0.625 (0.623–0.627)

1.020 (1.014–1.025)

 

0.663 (0.661–0.666)

0.75 (0.746–0.755)

 
  

4

0.560 (0.558–0.562)

1.266 (1.257–1.275)

0.996 (0.993–1.000)

0.797 (0.792–0.801)

2.347 (2.322–2.372)

0.397 (0.369–0.399)

  

Dichlorovnl-dimeth prop carboacid

Iron, refigerated (μmol/L)

1

8.493 (8.428–8.559)

 

3.886 (3.878–3.895)

4.601 (4.567–4.626)

0.359 (0.357–0.362)

0.880(0.877–0.883)

3.361 (3.346–3.376)

0.001

  

2

0.938 (0.933–0.944)

0.342 (0.340–0.345)

1.577 (1.573–1.580)

0.889 (0.886–0.892)

1.407 (1.401–1.413)

0.665(0.662–0.667)

1.912 (1.906–1.918)

 
  

3

 

3.832 (3.815–3.850)

0.668 (0.665–0.670)

0.253 (0.251–0.255)

 

1.322(1.317–1.326)

6.981 (6.952–7.011)

 
  

4

0.077 (0.076–0.077)

 

2.347 (2.341–2.353)

0.424 (0.421–0.427)

0.321 (0.318–0.324)

   
 

Uric acid (mg/dL)

1

 

1.375 (1.368–1.382)

0.910 (0.907–0.913)

2.542 (2.530–2.555)

0.650 (0.645–0.655)

0.214 (0.213–0.216)

3.631 (3.618–3.643)

 
  

2

  

1.276 (1.273–1.280)

0.554 (0.551–0.557)

 

0.966 (0.963–0.969)

2.306 (2.299–2.313)

 
  

3

0.547 (0.542–0.552)

1.066 (1.062–1.071)

3.610 (3.602–3.618)

0.832 (0.829–0.835)

0.599 (0.596–0.602)

1.019 (1.015–1.023)

  
  

4

1.185 (1.180–1.190)

 

2.683 (2.677–2.688)

0.135 (0.134–0.136)

0.771 (0.768–0.775)

0.281 (0.279–0.282)

1.056 (1.048–1.064)

 
  1. ALT Alanine aminotransferase
  2. AST Aspartate aminotransferase
  3. GGT Gamma glutamyl transferase
  4. Bold indicates when the OR values showed a clear and stable positive or negative correlation with the levels of oxidative stress markers