Table 2 Criteria to identify candidates for substitution

Mutagen Class 1A or 1B^a

Cannot be authorised

✓^b

✓

Carcinogen Class 1A or 1B^a

✓^c

✓

✓

Toxic for reproduction Class 1A or 1B^a

✓^c

✓^b

✓

Endocrine disrupting properties^d

✓^c

✓^b

✓

Lower ADI, ARfD or AOEL than the majority of approved substances^e

In the same group of substance/use category

In the same product-type and use scenario

Not applied

Persistent, Bioaccumulative and Toxic (PBT)^f

2 of 3 criteria

2 of 3 criteria

3 of 3 criteria

Very Persistent, very Bioaccumulative (vPvB)^f

Not applied

✓^b

✓

Respiratory sensitiser properties^g

Not applied

✓

✓

Significant proportion of non-active isomers or impurities

✓^h

✓

Not applied

Other concerns associated with critical effects in combination with use/exposure patterns, in particular risks to groundwater

✓

✓

Not applied

Equivalent level of concern linked to probable serious effects to human health or the environment^d

Not applied

Not applied

✓