Table 6 Overall agreement, sensitivities, and specificities of in vivo mammalian long-term reproductive toxicities, in vitro activities, and structural alerts of potential EA-EDs
n | Overall agreement (%) | Sensitivity (%) | Specificity (%) | |
|---|---|---|---|---|
In vitro/structural alerts (all compounds with in vitro data) | 744 | 79.8 | 83.7 | 77.1 |
In vitro/structural alerts (all compounds with in vitro and in vivo data) | 51 | 84.3 | 79.2 | 88.9 |
In vivo/in vitro (all compounds with in vitro and in vivo data) | 51 | 52.9 | 50.0 | 100 |
In vivo/structural alerts (all compounds with in vitro and in vivo data) | 51 | 49.0 | 45.8 | 100 |
In vivo/structural alerts (all compounds with in vivo data) | 240 | 20.0 | 15.4 | 100 |