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Environmental Sciences Europe

Table 5 Comparison of in vivo mammalian long-term reproductive toxicities and in vitro activities of potential EA-EDs (numbers of chemicals, n = 51)

From: Screening for potential endocrine disruptors in fish: evidence from structural alerts and in vitro and in vivo toxicological assays

 

In vitro very high activity

In vitro high activity

In vitro moderate activity

In vitro weak activity

In vitro very weak or no activity

Σ

In vivo active

6

6

11

1

24

48

In vivo inactive

0

0

0

0

3

3

Σ

6

6

11

1

27

51

  1. Accuracy = 52.9% (overall agreement)
  2. Sensitivity = 100% (→no false-negative classifications)
  3. Specificity = 50.0% (→50% false-positive classifications)
  4. Mammalian long-term reproductive toxicants: in vivo active: causing specific endpoints indicative for endocrine activity, in vivo inactive: not causing specific outcomes in the available study/studies
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