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Environmental Sciences Europe

Table 4 Comparison of in vitro activities and structural alerts of potential EA-EDs (numbers of chemicals, n = 744)

From: Screening for potential endocrine disruptors in fish: evidence from structural alerts and in vitro and in vivo toxicological assays

 

In vitro very high activity

In vitro high activity

In vitro moderate activity

In vitro weak activity

In vitro very weak or no activity

Σ

Structural alert = yes

33

60

84

80

100

357

Structural alert = no

2

6

26

16

337

387

Σ

35

66

110

96

437

744

  1. Accuracy = 79.8% (overall agreement)
  2. Sensitivity = 83.7% (→16.3% false-negative classifications)
  3. Specificity = 77.1% (→22.9% false-positive classifications)
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