Table 1 In vitro assays and their modes of action
Name/ s of assay | Mode of action/ endpoint |
|---|---|
AR CALUX (anti-) | Androgen receptor (activation or blocking) |
DR CALUX | AH receptor binding |
ER CALUX (anti-) | Alpha and beta/estrogen receptors |
GR CALUX (anti-) | Glucocorticoid receptor |
PAH CALUX | AH receptor binding |
PR CALUX | Progesterone receptor |
Acetylcholinesterase inhibition assay | Inhibition of acetylcholinesterase activity |
Carboxylesterase inhibition assay | Inhibition of carboxylesterase activity |
Ames | Mutagenicity |
umuC | Primary DNA damage |
TTR-binding | Competition with thyroid hormone for binding to TTR (transport protein) |
TRb CALUX | Thyroid receptor beta |
EROD | EROD induction |
YES | ER receptor |
YAS | AR receptor |
P-53 accumulation | Genotoxicity |
Green screen | Genotoxicity |
RYA | ER receptor |
ABC assay | Antibiotic activity |